Adamantane-1-sulfinyl Chloride → (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-1-adamantanesulfinamide

반응식

[C:1]12([S:11](Cl)=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH2:14][C@H:15]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:16]1>>[C:22]1([CH2:21][CH2:20][N:17]2[CH2:18][CH2:19][CH:15]([NH:14][S@:11]([C:1]34[CH2:10][CH:5]5[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]5)[CH2:2]3)[CH2:8]4)=[O:12])[CH2:16]2)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

참가 물질

반응물 2

HCID 4737333Adamantane-1-sulfinyl Chloride

HCID 10774056(3S)-1-(2-Phenylethyl)-3-pyrrolidinamine

생성물 1

HCID 70172045(S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-1-adamantanesulfinamide

실험 절차

1-Adamantanesulfinyl chloride and (S)-3-amino-1-(2-phenylethyl)pyrrolidine were reacted under the same conditions as in Example 53 to give (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-1-adamantanesulfinamide.

출처 및 근거

ORD 기록: ord-6a8c467211484f968e7c3809e41d3fbd
출처 데이터셋: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06468998B1

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