3-Methyl-2-thiophenecarboxaldehyde → 3-[(3-Methylthien-2-yl)methylene]-2-indolinone

HRID 992472노트

반응식

HRID 992472 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH3:11][C:12]1[CH:16]=[CH:15][S:14][C:13]=1[CH:17]=O>N1CCCCC1.C(O)C>[CH3:11][C:12]1[CH:16]=[CH:15][S:14][C:13]=1[CH:17]=[C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]1=[O:10]

참가 물질

5

반응물 2

HCID 799113-Methyl-2-thiophenecarboxaldehydeHCID 321710Oxindole

생성물 1

HCID 32759743-[(3-Methylthien-2-yl)methylene]-2-indolinone수율 65%

시약·촉매·용매 2

HCID 8082Piperidine촉매HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

A reaction mixture of 134.0 mg of oxindole, 151.4 mg of the 3-methylthiophene-2-carboxaldehyde, and 3 drops of piperidine in 2 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 157.8 mg (65%) of the title compound as a yellow solid.

후처리

  1. temperatureAfter cooling
  2. filtrationthe precipitate was filtered
  3. washwashed with cold ethanol
  4. customdried

출처 및 근거

ORD 기록
ord-b5c441b79e5d4e58b41aea2408667a29
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06469032B2

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