Pyrazole → 3-(1h-pyrazol-1-yl)benzaldehyde
반응식
[CH:1]([C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][CH:8]=1)=[O:2].[NH:12]1[CH:16]=[CH:15][CH:14]=[N:13]1.N1C=CC=CC=1>ClCCl.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[N:12]1([C:5]2[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=2)[CH:1]=[O:2])[CH:16]=[CH:15][CH:14]=[N:13]1참가 물질
6
실험 절차
A mixture of 3-formylphenylboronic acid (2.00 g, 13.34 mmol), pyrazole (0.46 g, 6.67 mmol), copper(II) acetate (1.82 g, 10.01 mmol), pyridine (1.10 mL, 13.34 mmol), and powdered 4A molecular sieves (2.5 g) in dichloromethane (20 mL) was stirred under an air atmosphere for 24 h. The mixture was then filtered through Celite, the filtered solids were washed with MeOH, and the combined filtrate was concentrated. Purification by chromatography (SiO2, 3:1 hexane/ethyl acetate) yielded the title compound.
후처리
- filtrationThe mixture was then filtered through Celite
- washthe filtered solids were washed with MeOH
- concentrationthe combined filtrate was concentrated
- customPurification by chromatography (SiO2, 3:1 hexane/ethyl acetate)
출처 및 근거
- ORD 기록
- ord-3e66280fab2c44eea426045eb37f5b1e
- 출처 데이터셋
- uspto-grants-2002_10
- 특허 번호
- US06472372B1
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