Water → HCID 18408501, 화합물

HRID 992985노트

반응식

HRID 992985 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[S:14][CH:15]=[C:16]([C:18](OCC)=[O:19])[N:17]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.S([O-])([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[OH:19][CH2:18][C:16]1[N:17]=[C:13]([C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=2)[S:14][CH:15]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 24436Sodium SulfateHCID 18408534HCID 18408534, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 18408501HCID 18408501, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

Ethyl 2-(3,4,5-trimethoxyphenyl)thiazole-4-carboxylate (6.9 g) was dissolved in THF (100 mL), and to the solution lithium aluminum hydride (810 mg) was added under an argon atmosphere, and the mixture was stirred at 0° C. for 1 hour. After a small amount of water and then sodium sulfate were added to the reaction mixture, the reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The resultant crude crystals were recrystallized from ethyl acetate-hexane to obtain the title compound.

후처리

  1. filtrationthe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe resultant crude crystals were recrystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-e86c20bb70d64800a1b1d552c7a60612
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06472386B1

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