Thionyl Chloride → HCID 12010380, 화합물

HRID 992986노트

반응식

HRID 992986 반응식
O[CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)[S:6][CH:7]=1.S(Cl)([Cl:22])=O>ClCCl>[Cl:22][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)[S:6][CH:7]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 18408501HCID 18408501, 화합물

생성물 1

HCID 12010380HCID 12010380, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Hydroxymethyl-2-(3,4,5-trimethoxyphenyl)thiazole (2.0 g) was dissolved in dichloromethane (60 mL), and to the solution thionyl chloride (1.1 g) was added at 0° C. After 30 minutes, the mixture was warmed to room temperature and stirred for 4 hours. The reaction mixture was washed with water and saturated brine and dried over anhydrous sodium sulfate. After concentrating the reaction mixture under reduced pressure, the resultant crude crystals were recrystallized from chloroform-hexane to obtain the title compound.

후처리

  1. washThe reaction mixture was washed with water and saturated brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationAfter concentrating the reaction mixture under reduced pressure
  4. customthe resultant crude crystals were recrystallized from chloroform-hexane

출처 및 근거

ORD 기록
ord-8adfac5c3aec49198ad8a4b90cf5a1db
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06472386B1

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