Hexahydro-1,4-diazepine → N,N'-bis[[1-Methyl-3-(3,4,5-trimethoxy-phenyl)pyrazol-5-yl]methyl]homopiperazine

HRID 993012노트

반응식

HRID 993012 반응식
Cl[CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)[CH:4]=1.[NH:21]1[CH2:27][CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:8][N:7]1[C:3]([CH2:2][N:21]2[CH2:27][CH2:26][CH2:25][N:24]([CH2:2][C:3]3[N:7]([CH3:8])[N:6]=[C:5]([C:9]4[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=4)[CH:4]=3)[CH2:23][CH2:22]2)=[CH:4][C:5]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)=[N:6]1

참가 물질

3

반응물 2

HCID 68163Hexahydro-1,4-diazepineHCID 184084865-Chloromethyl-1-methyl-3-(3,4,5-trimethoxy-phenyl)pyrazole

생성물 1

HCID 10282613N,N'-bis[[1-Methyl-3-(3,4,5-trimethoxy-phenyl)pyrazol-5-yl]methyl]homopiperazine

실험 절차

5-Chloromethyl-1-methyl-3-(3,4,5-trimethoxy-phenyl)pyrazole (119 mg) and homopiperazine (20 mg) were reacted in the same manner in Example 1 to obtain the title compound as a free base.

출처 및 근거

ORD 기록
ord-7cf00be08ab44a738c727ec51cbd2f09
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06472386B1

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