Piperazine → N,N'-bis[[5-(3,4,5-Trimethoxyphenyl)-thiophen-2-yl]methyl]piperazine Dimaleate

HRID 993037노트

반응식

HRID 993037 반응식
O[CH2:2][C:3]1[S:4][C:5]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)=[CH:6][CH:7]=1.Cl[CH2:21][C:22]1[S:23][C:24]([C:27]2[CH:32]=[C:31]([O:33][CH3:34])[C:30]([O:35][CH3:36])=[C:29]([O:37][CH3:38])[CH:28]=2)=[CH:25][CH:26]=1.[NH:39]1[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]1.[C:45]([OH:52])(=[O:51])/[CH:46]=[CH:47]\[C:48]([OH:50])=[O:49]>CO>[C:45]([OH:52])(=[O:51])/[CH:46]=[CH:47]\[C:48]([OH:50])=[O:49].[C:45]([OH:52])(=[O:51])/[CH:46]=[CH:47]\[C:48]([OH:50])=[O:49].[CH3:19][O:18][C:10]1[CH:9]=[C:8]([C:5]2[S:4][C:3]([CH2:2][N:39]3[CH2:44][CH2:43][N:42]([CH2:21][C:22]4[S:23][C:24]([C:27]5[CH:32]=[C:31]([O:33][CH3:34])[C:30]([O:35][CH3:36])=[C:29]([O:37][CH3:38])[CH:28]=5)=[CH:25][CH:26]=4)[CH2:41][CH2:40]3)=[CH:7][CH:6]=2)[CH:13]=[C:12]([O:14][CH3:15])[C:11]=1[O:16][CH3:17]

참가 물질

6

반응물 4

HCID 4837PiperazineHCID 444266Maleic AcidHCID 184084922-Hydroxymethyl-5-(3,4,5-trimethoxyphenyl)thiopheneHCID 184085302-Chloromethyl-5-(3,4,5-trimethoxyphenyl)thiophene

생성물 1

HCID 86758582N,N'-bis[[5-(3,4,5-Trimethoxyphenyl)-thiophen-2-yl]methyl]piperazine Dimaleate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Hydroxymethyl-5-(3,4,5-trimethoxyphenyl)thiophene (234 mg) was treated in the same manner in Preparation Example 4 to synthesize 2-chloromethyl-5-(3,4,5-trimethoxyphenyl)thiophene. Since this product was unstable, it was immediately reacted with piperazine (36 mg) in the same manner in Example 1 without isolating it to obtain a product as a free base. This product was dissolved in methanol, and maleic acid was added to the solution, thereby converting it into the title compound.

후처리

  1. customwithout isolating it
  2. customto obtain a product as a free base

출처 및 근거

ORD 기록
ord-591f3b5d6a5e4566a6c25b03327464b8
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06472386B1

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