Thionyl Chloride → (2-Chloro-4-methoxyphenyl)acetyl chloride

HRID 993233노트

반응식

HRID 993233 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([OH:13])=O.S(Cl)([Cl:16])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([Cl:16])=[O:13]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 42091322-(2-Chloro-4-methoxyphenyl)acetic acid

생성물 1

HCID 22327520(2-Chloro-4-methoxyphenyl)acetyl chloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

160 g of 2-chloro-4-methoxyphenylacetic acid are suspended in 210 ml of toluene, and the suspension is stirred together with 96 ml of thionyl chloride at 80° C. until the evolution of gas has ceased. The volatile components are stripped off, and the residue is distilled. 90 g of an orange oil are obtained (thin-film evaporator 170° C., 0.08 mbar).

후처리

  1. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-0ee89368526f46f4ae24d850a0f783e7
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06472419B1

반응 노트

불러오는 중…