참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Boron Trichloride | HCID 25135 | — |
| 반응물 | Raloxifene Bismethyl Ether | HCID 10767755 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Raloxifene Bismethyl Ether (hydrochloride) | HCID 45260096 | — |
반응 단계
A mixture of the compound prepared as described in Preparation 1 (8.46 grams) and the acid chloride prepared as described in Preparation 4 (10.0 grams) in methylene chloride (350 mL) was cooled to about 20-25° C. The cool mixture was treated with boron trichloride (2.6 mL), and the resulting mixture mechanically stirred. The reaction was monitored by HPLC using the assay described above. After 85 minutes, the in situ HPLC yield based on a 6-methoxy-2-(4-methoxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene standard was 88%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06472531B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_10 |
|---|
| ORD ID | ord-c73cf8880a6b47c7a233939a9f00e779 |
|---|
| 출처 메모 | uspto-grants-2002_10 |
|---|
