HCID 22891997, 화합물 → HCID 69940044, 화합물

HRID 993435노트

반응식

HRID 993435 반응식
[CH2:1]([O:8]C([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][N:18]2[C:22]([CH2:23][N:24]3[CH:28]=[C:27]([C:29]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)=[O:30])[C:26]([C:37]4[C:46]5[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=5)[CH:40]=[CH:39][CH:38]=4)=[N:25]3)=[CH:21][N:20]=[CH:19]2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[H][H]>CO.[C+4].[OH-].[Pd+2].[OH-].[OH-].[OH-].[OH-].[OH-]>[OH2:8].[NH3:11].[CH3:1][OH:8].[NH:11]1[CH2:12][CH2:13][CH:14]([CH2:17][N:18]2[C:22]([CH2:23][N:24]3[CH:28]=[C:27]([C:29]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)=[O:30])[C:26]([C:37]4[C:46]5[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=5)[CH:40]=[CH:39][CH:38]=4)=[N:25]3)=[CH:21][N:20]=[CH:19]2)[CH2:15][CH2:16]1

참가 물질

6

반응물 2

HCID 22891997HCID 22891997, 화합물HCID 178418361HCID 178418361, 화합물

생성물 2

HCID 69940044HCID 69940044, 화합물수율 144.4%HCID 140995658HCID 140995658, 화합물

시약·촉매·용매 2

HCID 178420936HCID 178420936, 화합물촉매HCID 887Methanol용매

실험 절차

227 mg (0.36 mmol) of the compound prepared in Example 158 was dissolved in methanol, 20 mg of palladium hydroxide carbon was added thereto, and the mixture was reacted under 1 atm of hydrogen for 2 hours. After the reaction was completed, the mixture was filtered and the solvent therein was removed. The residue was subjected to silica gel column chromatography(eluent: ammonia water/methanol=15/85, v/v) to give 120 mg (0.26 mmol, Yield 74%) of the title compound.

후처리

  1. filtrationthe mixture was filtered
  2. customthe solvent therein was removed

출처 및 근거

ORD 기록
ord-609d34d020a544c09ff8a043d3d4ad85
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06472526B1

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