Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → 3-[2-(2,4-Dichlorophenyl)ethoxy]-4-methoxybenzoic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 2,4-Dichlorophenethyl alcohol | HCID 2734099 | — |
| 반응물 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 반응물 | Ethyl 3-hydroxy-4-methoxybenzoate | HCID 15480330 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-[2-(2,4-Dichlorophenyl)ethoxy]-4-methoxybenzoic acid ethyl ester | HCID 15480331 | 38.2% |
반응 단계
To a solution of 10 g (38.3 mmol) of triphenylphosphane in 100 ml of THF were added 6.7 g (3.83 mmol) of DEAD over 5 min at room temperature. After 30 min at room temperature, 5 g (25.5 mmol) of 3-hydroxy-4-methoxybenzoic acid ethyl ester and 4.87 g (25.5 mmol) of 2-(2,4-dichlorophenyl)ethanol were added and the mixture was stirred at room temperature for 12 h. The solvent was removed and the residue was separated by chromatography to give 3.6 g (38%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06472562B1 |
| 출처 데이터셋 | uspto-grants-2002_10 |
| ORD ID | ord-2e555f1e061b4f3ba6fdac75682dcec8 |
| 출처 메모 | uspto-grants-2002_10 |