Glycine → HCID 178512182, compound

HRID 1003165Notes

Reaction equation

HRID 1003165 reaction equation
ON1C(=O)CCC1=O.[NH:9]([C:41]([O:43][CH2:44][C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)=[O:42])[C@@H:10]([C:38](O)=[O:39])[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[NH:37])[N:16]([C:27]([O:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:28])[C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18].[NH2:51][CH2:52][C:53]([OH:55])=[O:54]>>[NH:9]([C:41]([O:43][CH2:44][C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1)=[O:42])[C@@H:10]([C:38]([NH:51][CH2:52][C:53]([OH:55])=[O:54])=[O:39])[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[NH:37])[N:16]([C:27]([O:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)=[O:28])[C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18]

Participants

4

Reactant 3

HCID 750GlycineHCID 80170N-HydroxysuccinimideHCID 178512183HCID 178512183, compound

Product 1

HCID 178512182HCID 178512182, compoundYield 87%

Procedure

Cbz-D-Arg(Cbz)2-Gly-OH is prepared according to Example 1 by coupling the N-hydroxysuccinimide active ester of Cbz-D-Arg(Cbz)2-OH to glycine in a yield of 87%.

Sources & evidence

ORD record
ord-b163b12612714aa3bc4c6def9502ed32
Source dataset
uspto-grants-2000_04
Patent number
US06046169

Reaction notes

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