反应详情

2,4-di(benzyloxycarbonyl)buty(methyl)-O-benzylphosphinic acid (0.8 g, 1.6 mmol) in 20 mL of water containing 100 mg of 10% Pd/C was hydrogenated at 40 psi for 4 hours. The mixture was filtered over a pad of Celite and evaporated at high vacuum to give 2-[(methylhydroxyphosphinyl)methyl]pentanedioic acid (4,R=CH3,0.28 g, 78% as a clear and colorless viscous oil. 1H NMR (D2O): 2.5 ppm(m,1H), 2.2 ppm(t,2H), 2.0 ppm (m,1H), 1.7 ppm(m,3H), 1.3 ppm (d, 3H) Elemental Analysis Calculated C7H13O6P.0.2 H2O: C36.92 H 5.93 Found: C37.06 H 6.31

1. filtrationThe mixture was filtered over a pad of Celite
2. customevaporated at high vacuum