反应详情

Benzyl[2,4-di(benzyloxycarbonyl)butyl]phosphinic acid(0.5 g, 1.0 mmol) in 20 mL of water containing 120 mg of 10% Pd/C was hydrogenated on a Parr hydrogenator at 40 psi for 6 hours. Filtration through a Celite pad followed by evaporation on high vacuum gave 0.17 g (57%) of 2-[(benzylhydroxyphosphinyl)methyl]pentanedioic acid(4,R=CH2Ph) as a white solid. 1H NMR (D2O): 7.1 ppm(m,5H), 2.9 ppm(d,2H), 2.4 ppm(m,1H), 2.1 ppm(t,2H), 1.8 ppm(m,1H), 1.6 ppm(m,3H) Elemental Analysis, Calculated C13H17O6P: C52.00H5.71: Found: C51.48H5.70

1. filtrationFiltration through a Celite pad
2. customfollowed by evaporation on high vacuum
3. customgave 0.17 g (57%) of 2-[(benzylhydroxyphosphinyl)methyl]pentanedioic acid(4,R=CH2Ph) as a white solid