HCID 69334832, compound → HCID 54495358, compound

Participants

Reaction Steps

To a solution of 3-benzyloxy-2-dimethylaminoestra-1,3,5(10)-trien-17-one (81, 0.666 g, 1.65 mmol) in THF (30 mL) was added 10% palladium on carbon (0.200 g). The reaction mixture was stirred for 1 h under a hydrogen atmosphere at room temperature. After the catalyst was filtered, the solvent was evaporated at reduced pressure. The residue was purified by column chromatography (silica gel) using n-hexane:EtOAc (3:1→2:1, v/v) to afford 0.462 g of 82 (89% yield) mp: 160-161° C.

Provenance & Evidence