3-Benzyloxy-4-dimethylaminoestra-1,3,5(10)-trien-17-one → HCID 54174043, compound

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Reaction Steps

To a solution of 3-benzyloxy-4-dimethylaminoestra-1,3,5(10)-trien-17-one (86, 0.271 g, 0.67 mmol) in THF (10 mL) was added 10% palladium on carbon (0.200 g). The reaction mixture was stirred for 1 h under a hydrogen atmosphere at room temperature. After the catalyst was filtered, the solvent was evaporated at reduced pressure. The residue was purified by column chromatography (silica gel) using n-hexane:EtOAc (5:1→3:1, v/v) to afford 0.171 g of 87 (81% yield) mp: 155-156° C.

Provenance & Evidence