HCID 10505011, compound → HCID 10050798, compound

Participants

Reaction Steps

A mixture of the compound obtained in Example 5A (10.16 g), activated manganese dioxide (30.93 g) and toluene (200 ml) was stirred under refluxing conditions for 11.5 hours. The reaction mixture was filtered; the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane-methanol (20:20:1, v/v) to yield ethyl 2-(N,N-diethylaminomethyl)-4-(3,4-dimethoxyphenyl)thieno[2,3-b:5,4-c']dipyridine-3-carboxylate (for structural formula, see below) (3.1 g, 31%), which was then recrystallized from ethyl acetate to yield colorless needle crystals having a melting point of 163 to 165° C. ##STR47##

Provenance & Evidence