huagongshe.com
HRID1003234

反应详情

EQUATION

反应方程式

HRID 1003234 的结构方程式

REACTANTS

反应物

2
结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：CC(C)[C@@H]1CC(O)OC([C@@H](C)[C@H]2CC(=O)[C@H]3[C@@H]4CCC5CC(O)CC[C@]5(C)[C@H]4CC[C@]23C)C1
HCID53902136

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)[C@@H]1CC(O)OC([C@@H](C)[C@H]2CC(=O)[C@@H]3[C@@H]4CCC5CC(O)CC[C@]5(C)[C@H]4CC[C@]23C)C1
HCID69625815

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Epimerization of compound 248 at the C14 position using KOH in MeOH yields 22,29-epoxy-3,29-dihydroxy-14β-stigmastan-15-one (260). Compound 248 is dissolved in MeOH and a solution of KOH in MeOH (25 mg/ml) is added. The mixture is refluxed for 15 minutes then cooled to room temperature. Water is added and the aqueous slurry is extracted with chloroform and then dried over MgSO4. Filtration and concentration gives the crude product that contains an epimeric mixture of compounds 248 and 260. Separation of 248 and 260 is achieved using column chromatography.