HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxy-2-nitropyridine → HCID 18795892, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxy-2-nitropyridine | HCID 27057 | — |
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 18795892 | HCID 18795892 | 76% |
Reaction Steps
This compound was prepared from ethyl 4-bromobutyrate 2 and 2-nitro-3-pyridinol (39) via the procedure of Step (A), supra. Following flash chromatography (silica gel; 1.5% methanol/methylene chloride eluant) a dilute sodium bicarbonate wash of an ether solution of the product was necessary to remove traces of starting phenol. The product (40) was obtained in 76% yield as a pale yelow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06046183 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-787f47963d6846ae8571a02d21de7faa |
| Source note | uspto-grants-2000_04 |