HCID 53730197, compound → HCID 54067144, compound

Participants

Reaction Steps

Ethyl (s)-4-[2-(tert-butoxycarbonylamino)-1,2,3,4-tetra-hydronaphthalen-7-yloxy]butyrate (988 mg) was dissolved in a mixed solvent of methanol (15 ml) and ethanol (15 ml), and 2N aqueous sodium hydroxide solution (3.0 ml) was added to the solution at room temperature with stirring. After reaction for 2 hours, the reaction mixture was concentrated in vacuo. To the resulting residue was added 10% aqueous citric acid solution, and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. The solvent was removed in vacuo to give (S)-4-[2-(tert-butoxycarbonylamino)-1,2,3,4-tetrahydronaphthalen-7-yloxy]butyric acid (914 mg) having a melting point of 150-153° C.

Provenance & Evidence