Potassium Iodide → N-(12-Iodododecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.26 g of potassium iodide in 2 ml of phosphoric acid was added 0.10 g of N-(12-hydroxydodecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide and the mixture was stirred at 110° C. for 3 hours. The reaction solution was diluted with water, and a saturated aqueous solution of sodium hydrogen carbonate and an aqueous solution of sodium thiosulfate were added. The mixture was extracted with chloroform. The organic layer was washed with water and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to afford 0.11 g of the title compound.

Provenance & Evidence