反应详情

温度

160 °C

To 2.78 g of N-(12-hydroxydodecyl)-6-chloropyridine-3-carboxamide was added 4.15 g of 1-isopropylpiperazine and the mixture was stirred at 160° C. for 30 minutes. The reaction solution was diluted with chloroform, washed with water, dried over anhydrous sodium sulfate and distilled off under reduced pressure. The residue was chromatographed over a silica gel column to afford 2.2 g of the title compound as a crystal.

1. washwashed with water
2. dry with materialdried over anhydrous sodium sulfate
3. distillationdistilled off under reduced pressure
4. customThe residue was chromatographed over a silica gel column