反应详情

A solution of 3.1 g of sodium hydroxide in 15 ml of water was added to 75 ml of methanol. 15 g of methyl 6-(4-ethyl-1-piperazinyl)pyridine-3-carboxylate was added and the mixture was heated under reflux for 1.5 hours. The solvent was distilled off under reduced pressure, to the resulting residue was added hot acetone and the crystal thus precipitated out was recovered by filtration. It was again washed with hot acetone to afford 17.2 g of the title compound as a crystal.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1.5 hours
3. distillationThe solvent was distilled off under reduced pressure, to the resulting residue
4. additionwas added hot acetone
5. customthe crystal thus precipitated out
6. filtrationwas recovered by filtration
7. washIt was again washed with hot acetone