Potassium Hydroxide → 1-Isopropylpiperazine

HRID 1003321Notes

Reaction equation

HRID 1003321 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([CH:10]([CH3:12])[CH3:11])[CH2:6][CH2:5]1)(=O)C.[OH-].[K+]>CO>[CH:10]([N:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1)([CH3:12])[CH3:11]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 187964191-[4-(Propan-2-yl)piperazin-1-yl]ethan-1-one

Product 1

HCID 780131-IsopropylpiperazineYield 105.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 7.26 g of 1-acetyl-4-isopropylpiperazine were added 100 ml of methanol and 10 g of potassium hydroxide and the mixture was heated under reflux for 17 hours. After the solvent was distilled off, water and chloroform were added. The mixture was extracted with chloroform and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to afford 5.78 g of the title compound as an oily substance.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 17 hours
  3. distillationAfter the solvent was distilled off
  4. additionwater and chloroform were added
  5. extractionThe mixture was extracted with chloroform
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-e6d544aed0e04eabb6fdd9f3a082a8f0
Source dataset
uspto-grants-2000_04
Patent number
US06046201

Reaction notes

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