Hydrochloric Acid → HCID 18796453, compound

Participants

Reaction Steps

In 125 ml of dry methanol was dissolved 5-methoxy-2-[[(1-methylethylidene)-amino]oxy]benzonitrile (10 g), followed by 125 ml of ethereal hydrochloric acid. The reaction was stirred under nitrogen overnight. The reaction was neutralized with saturated sodium carbonate solution and extracted with EtOAc. The organic layer was dried and concentrated in vacuo. Recrystallization of the residue from dichloromethane/petroleum ether afforded the expected product (6.8 g).

Provenance & Evidence