HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1003408Generated: October 31, 2026
Potassium Carbonate → HCID 54413738, compound
https://huagongshe.com/reaction/1003408
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(Diethylboryl)pyridine | HCID 642851 | — |
| Reactant | HCID 18796944 | HCID 18796944 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 54413738 | HCID 54413738 | 80% |
Reaction Steps
A solution of the methyl 7-amino-2-chloro-thieno[2,3-b]pyrazine-6carboxylate prepared as described in Example 10C (0.468 g), diethyl(3-pyridyl)borane (0.293 g), Pd(dppf)Cl2 (0.157 g), and K2CO3 (0.800 g) in degassed DMF (10 mL) was heated to 95° C. for 1.5 h, cooled, quenched in sat'd NH4Cl, the solid precipitate collected, washed with water and dried. Purification by silica gel column chromatographed provided 0.44 g (80%) of the title compound. 1H NMR (DMSO-d6) δ 3.87 (3H, s), 7.25 (2H, br s), 7.6 (1H, dd), 8.75 (2H, m), 9.49 (1H, s), 9.58 (1H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06046207 |
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| Source dataset | uspto-grants-2000_04 |
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| ORD ID | ord-ec3ad39364654ef1b35f413a0e4aa361 |
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| Source note | uspto-grants-2000_04 |
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