Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) → (trans)-3a,4,5,6,7,7a-Hexahydro-3-methoxy-1h-isoindole

HRID 1003451Notes

Reaction equation

HRID 1003451 reaction equation
[C:1]1(=[O:10])[C@H:9]2[C@@H:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:3][NH:2]1.F[B-](F)(F)F.[CH3:16][O+](C)C>>[CH3:16][O:10][C:1]1[C@H:9]2[C@@H:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:3][N:2]=1

Participants

3

Reactant 2

HCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 13039544rac-(3aR,7aR)-octahydro-1H-isoindol-1-one

Product 1

HCID 70148411(trans)-3a,4,5,6,7,7a-Hexahydro-3-methoxy-1h-isoindole

Procedure

A sample of the title compound of EXAMPLE 171 (1.39 g, 10 mmol) was reacted with trimethyloxonium tetrafluoroborate (1.78 g, 12 mmol) by the method of EXAMPLE 26 to yield, after chromatography, 1.05 g (69%) of the title material.

Workup

  1. customto yield

Sources & evidence

ORD record
ord-755426d3aec04256954648390ab2d5c2
Source dataset
uspto-grants-2000_04
Patent number
US06046211

Reaction notes

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