HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Morpholine oxide | HCID 15900019 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Reactant | HCID 178439094 | HCID 178439094 | — |
| Catalyst | Osmium Tetroxide | HCID 30318 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 3-(7-Iminoazepin-2-yl)-1,2-propanediol, monohydrochloride | HCID 67779708 | — |
Reaction Steps
To the product of EXAMPLE 108 in a mixture of acetone and THF is added osmium tetroxide. An aqueous solution of morpholine N-oxide is then added to the reaction and the mixture is stirred at room temperature over night. Sodium bisulfite is then added and this mixture is evaporated in vacuo to a solid. The solid is extracted with methanol thrice, and the combined extracts are evaporated in vacuo to a solid. This solid is dissolved in water and applied to a Dowex-50 ion exchange column (H+), which is eluted with water and then 0.2 N HCl to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06046211 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-98ecb8e056d94d8aafb2b119bb9690dc |
| Source note | uspto-grants-2000_04 |