2-Aminoisoquinoline → 2-Amino-5,6,7,8-tetrahydroisoquinoline acetate

HRID 1003485Notes

Reaction equation

HRID 1003485 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].N=C1CC(C)CCN1.[NH2:13][N:14]1[CH:23]=[CH:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15]1>>[C:1]([OH:4])(=[O:3])[CH3:2].[NH2:13][N:14]1[CH:23]=[CH:22][C:21]2[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=2[CH2:15]1

Participants

3

Reactant 2

HCID 226396282-AminoisoquinolineHCID 1784758702-Imino-4-methylpiperidine acetate

Product 1

HCID 184285932-Amino-5,6,7,8-tetrahydroisoquinoline acetate

Procedure

The method of preparation of 2-imino-4-methylpiperidine acetate was used to convert 2-aminoisoquinoline to the title compound except platinum oxide was used as the catalyst. The product was triturated with EtOH to give a white solid. The analysis of the product was found to be consistent with the proposed structure. 1H NMR (D2O): δ 7.35 (d, J=6 Hz, 1H); 6.55 (d, J=6 Hz, 1H); 2.6-2.5 (m, 2H); 2.20-2.10 (m, 2H); 1.75 (s, 3H); 1.70-1.50 (m, 4H).

Sources & evidence

ORD record
ord-d697ad4081544f2a9dc38ca2c353c996
Source dataset
uspto-grants-2000_04
Patent number
US06046211

Reaction notes

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