Pyridine-2,5-diamine dihydrochloride → HCID 178479087, compound

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Reaction Steps

2,5-diaminopyridine dihydrochloride (1.2 g) and platinum oxide (500 mg) in ethanol (20 mL) and conc HCl (2 mL) were shaken on a Parr hydrogenation apparatus at 55 psi of hydrogen overnight. Product was obtained as a dark solid which was purified by C-18-reverse phase chromatography, eluting with H2O/CH3CN. Fractions containing the product were lyophilized, redissolved in 1N HCl and lyophilized to give the product as a yellow solid. The analysis of the product was found to be consistent with the proposed structure. MH+=114; 1H NMR (D2O): δ3.8-3.6 (m, 2H); 3.4-3.25 (m, 1H); 2.75-2.65 (m, 2H); 2.25-2.15 (m, 1H); 2.15-1.85 (m, 1H).

Provenance & Evidence