反应详情

10 ml of ethanol and 197 mg of sodium borohydride were added to 200 mg of 4-(α-ethoxycarbonyl-3,4-methylenedioxybenzyl)amino-6-chloroquinazoline. The obtained mixture was refluxed for 30 minutes, followed by the addition of 5 ml of water. The obtained mixture was concentrated under a reduced pressure, followed by the addition of 10 ml of water. The crystal thus precipitated was recovered by filtration. Thus, 30 mg of the title compound was obtained.

1. temperatureThe obtained mixture was refluxed for 30 minutes
2. concentrationThe obtained mixture was concentrated under a reduced pressure
3. additionfollowed by the addition of 10 ml of water
4. customThe crystal thus precipitated
5. filtrationwas recovered by filtration