1-Benzyl-4-piperidone → HCID 18797152, compound

HRID 1003553Notes

Reaction equation

HRID 1003553 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][CH:12]=[C:11]3[C:7]=2[CH:8]=[CH:9][NH:10]3)[CH2:3][CH2:2]1.[CH2:15]([N:22]1[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][CH:12]=[C:11]3[C:7]=2[C:8]([C:25]2[CH2:26][CH2:27][N:22]([CH2:15][C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH2:23][CH:24]=2)=[CH:9][NH:10]3)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 192201-Benzyl-4-piperidoneHCID 212682944-Cyclopropylmethoxyindole

Product 1

HCID 18797152HCID 18797152, compoundYield 23.3%

Procedure

Beginning with 3.77 gm (20.1 mMol) 4-cyclopropylmethyloxy-1H-indole and 7.5 mL (40.3 mMol) 1-benzyl-4-piperidone, 1.68 gm (23%) of the title compound were recovered as an off white solid.

Sources & evidence

ORD record
ord-98c18eafecec446996375c467d80e492
Source dataset
uspto-grants-2000_04
Patent number
US06046215

Reaction notes

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