HCID 21268342, compound → HCID 18797335, compound

HRID 1003576Notes

Reaction equation

HRID 1003576 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([C:10]3(O)[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]3)=[CH:7][C:6]=2[CH:24]=1>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([C:10]3[CH2:15][CH2:14][NH:13][CH2:12][CH:11]=3)=[CH:7][C:6]=2[CH:24]=1

Participants

3

Reactant 1

HCID 21268342HCID 21268342, compound

Product 1

HCID 18797335HCID 18797335, compoundYield 65.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 0.998 gm (2.72 mMol) 5-chloro-2-(4-hydroxy-1-(tert-butoxycarbonyl)piperidin-4-yl)benzothiophene in 10.0 mL dichloromethane was subjected to the reaction conditions described in the previous example, providing 0.444 gm (65%) of 5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)benzothiophene as a tan solid. This material was dissolved in ethyl acetate and the solution was treated with oxalic acid. The resulting solution was concentrated under reduced pressure to give the title compound.

Sources & evidence

ORD record
ord-90997a8be5014b0fb924a142ff72552a
Source dataset
uspto-grants-2000_04
Patent number
US06046215

Reaction notes

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