HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (R)-4-((tert-butyldiphenylsilyl)oxy)butan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| Reactant | (-)-1,3-Butanediol | HCID 637497 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-4-((tert-butyldiphenylsilyl)oxy)butan-2-ol | HCID 12032996 | — |
Reaction Steps
A mixture of (R)-1,3-butanediol (2 g), triethylamine (4 mL) and t-butyldiphenylchlorosilane (6.7 g) in CH2Cl2 (80 mL) was stirred at r.t. for 15 h. Saturated NH4Cl was added and the mixture was extracted with ethyl acetate. The combined organics were dried (MgSO4) and concentrated. Flash chromatography of the residue (9:1 hexane/ethyl acetate) provided the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06046217 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-354fc6f1ee274c7591d597129c474358 |
| Source note | uspto-grants-2000_04 |