HCID 22619444, compound → HCID 18357912, compound

HRID 1003641Notes

Reaction equation

HRID 1003641 reaction equation
O[CH:2]([C:19]1[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=1)[C:3]#[C:4][C:5]1[CH:14]=[CH:13][C:12]2[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9][C:8]([CH3:18])([CH3:17])[C:7]=2[CH:6]=1.CC1(C)CCC(C)(C)C2C=C(C#CCC3C=C(C=CC=3)C(O)=O)C=CC1=2>>[CH3:15][C:11]1([CH3:16])[CH2:10][CH2:9][C:8]([CH3:17])([CH3:18])[C:7]2[CH:6]=[C:5]([C:4]#[C:3][CH2:2][C:19]3[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=3)[CH:14]=[CH:13][C:12]1=2

Participants

3

Reactant 2

HCID 22619444HCID 22619444, compoundHCID 86755283HCID 86755283, compound

Product 1

HCID 18357912HCID 18357912, compound

Procedure

In a similar manner to Example 5(e), starting with 1.66 g (4.6 mmol) of 4-[1-hydroxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-propynyl]benzoic acid (prepared in Example 10(b) of patent EP 0,661,258), 310 mg (19.5%) of 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl-2-propynyl]benzoic acid are obtained, with a melting point of 159-60° C.

Workup

  1. customare obtained, with a melting point of 159-60° C.

Sources & evidence

ORD record
ord-f6e564c39e424dd98136af55349cba71
Source dataset
uspto-grants-2000_04
Patent number
US06046220

Reaction notes

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