Trifluoromethanesulfonic anhydride → HCID 22132527, compound

Participants

Reaction Steps

Trifluoromethanesulfonic anhydride (0.53 ml, 3.14 mmol) was added dropwise with stirring to an ice-cooled solution of 7-hydroxy-2-(4-phthalimidobutyl)-1,2,3,4-tetrahydroisoquinoline (1 g, 2.86 mmol) in anhydrous pyridine (10 ml). After stirring at room temperature for 18 h the reaction mixture was added to 10% aqueous Copper (II) sulfate (100 ml) and extracted into ethyl acetate (200 ml). The organic layer was separated, washed with 10% aqueous copper (II) sulfate (2×50 ml), dried (Na2SO4) and evaporated in vacuo. Chromatography on silica gel using 10-100% ethyl acetate-hexane gradient elution gave the title compound as a green oil (0.45 g, 33%).

Provenance & Evidence