Trifluoromethanesulfonic anhydride → HCID 18797032, compound

Participants

Reaction Steps

Trifluoromethanesulfonic anhydride (0.21 ml, 1.25 mmol) was added dropwise with stirring to an ice cooled solution of 2-(4-(4-(3-cyanophenyl)benzoylamino)butyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline (0.41 g, 0.96 mmol) in anhydrous pyridine (5 ml). After stirring at room temperature for 18 h. the mixture was poured into 10% aqueous copper (II) sulphate (100 ml). The mixture was extracted with ethyl acetate (2×50 ml) and the combined extracts washed with 10% aqueous copper (II) sulfate (2×50 ml). water (50 ml), dried (Na2SO4) and evaporated in vacuo. The residue was chromatographed on silica gel using 10-100% ethyl acetate-hexane gradient elution to afford the title compound (0.263 g, 49%).

Provenance & Evidence