2-Chlorobenzaldehyde → HCID 54543583, compound

Participants

Reaction Steps

16.64 g (0.118 mole) of 2-chloro-benzaldehyde (V) and 24.7 g (0.118 mole) of ethyl-4-(2-chloroethoxy)-acetoacetate (IV) are reacted in 365 ml of isopropanol in the presence of a piperidine acetate catalyst [10 g (11.8 millimoles) of piperidine+0.7 g (11.8 millimoles) of acetic acid] at room temperature for 10 hours. The reaction mixture is evaporated, the residual oil is dissolved in dichloro methane, washed with water and dried. The organic phase is evaporated in vacuo. Thus 37.9 g of the desired product are obtained in the form of a yellow oil, yield 97%.

Provenance & Evidence