2-Chlorobenzaldehyde → HCID 54282972, compound

Participants

Reaction Steps

10 g (33 millimoles) of ethyl-4-(2-iodoethoxy)-acetoacetate (XIII) and 4.64 g (33 millimoles) of 2-chloro-benzaldehyde (V) are reacted in 100 ml of isopropanol in the presence of a piperidine acetate catalyst [0.28 g (3.3 millimoles) of piperidine+0.198 g (3.3 millimoles) of acetic acid] at room temperature for 10 hours. The reaction mixture is evaporated, the residual oil dissolved in dichloro methane, washed with water and dried. The organic phase is evaporated in vacuo. Thus 11.55 g of the desired product are obtained in the form of a reddish brown oil, yield 83%.

Provenance & Evidence