Diethyl Ether → HCID 15462011, compound

Participants

Reaction Conditions

Reaction Steps

To 5-(3,4-difluorophenyl)-4-methoxycarbonyloxazole (1.0 g, 4.18 mmol) in methanol (6 mL), 1N HCl (2 mL) was added and the mixture was heated at 50° C. for 2 hours. The reaction mixture was then concentrated to yield a syrup. Ether was added and the solution filtered to give 1.0 g (87%) of the product as a white solid: 1H-NMR (CDCl3) 3.74 (s, 3 H), 6.15 (s, 1H), 7.45-7.55 (m, 1H), 8.11-8.13 (m, 2H)

Provenance & Evidence