Tetrahydrofuran → HCID 57266132, compound

Participants

Reaction Conditions

Reaction Steps

To 3-bromo-1-propylamine hydrobromide (1.0 g, 4.56 mmol) in THF (20 mL) was added triethylamine (2.31 g, 22.8 mmol). The mixture was cooled to -78° C., triturated with N-(chlorocarbonyl)isocyanate (723 mg, 6.85 mmol) and stirred for 10 min. It was then concentrated, and the residue was partitioned between EtOAc and water. The organic layer was dried over Na2SO4, filtered and concentrated to give, in quantitative yield, the crude product which was used without purification.

Provenance & Evidence