反应详情

To 1.7 l of toluene solution of 433 g of 1,3-dichloro-2-(2,4-difluorophenyl)-2-propanol was added 870 ml of 20% aqueous solution of potassium hydroxide. After the resulting liquid was stirred at room temperature for 3 hours, the organic layer was separated therefrom The aqueous layer was extracted twice with 1 l of ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate. The resulting organic layer as filtered and the solvent was removed under reduced pressure. Thus obtained concentrate was distilled under reduced pressure to give 184 g of the desired compound.

1. customthe organic layer was separated
2. extractionThe aqueous layer was extracted twice with 1 l of ethyl acetate
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationThe resulting organic layer as filtered
5. customthe solvent was removed under reduced pressure
6. customThus obtained
7. concentrationconcentrate
8. distillationwas distilled under reduced pressure