HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1H-Pyrazole-3,5-dicarboxylic acid, 4-hydroxy-, 3,5-diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ethyl diazoacetate | HCID 12192 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Dimethylmalonat | HCID 6946994 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1H-Pyrazole-3,5-dicarboxylic acid, 4-hydroxy-, 3,5-diethyl ester | HCID 54725492 | — |
Reaction Steps
Sodium methoxide (18.9 g, 0.35 moles) was suspended in methanol (400 ml) at 5° C. Dimethylmalonate (46.2, 0.35 moles) and ethyldiazoacetate (20 g, 0.175 moles) was added quickly and the reaction stirred at room temperature for 72 hours. The reaction was cooled to 5° C. and hydrochloric acid (70 ml of 5M) added; followed by 500 ml of water. The pH of the reaction was adjusted to 7 with sodium bicarbonate and the solids (22 g, 63%) collected by filtration. EA, MS
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06046227 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-7b4b2c73d9d24d43bc55ea36d25bda0e |
| Source note | uspto-grants-2000_04 |