Dimethylformamide → HCID 18793823, compound

Participants

Reaction Steps

Dimethylformamide (800 ml) was added to a mixture of succinimide (248 g, 2.5 mol), potassium carbonate (346 g, 2.5 mol) and ethyl 5-bromopentanoate (400 g, 1.9 mol). The mixture was heated at 110°-120° C. for 3 h before being cooled to RT. Water (2.5 L) was added and the mixture was extracted with methyl tert-butylether (4×1 L). The combined extracts were washed with water (400 ml), dried (MgSO4) and evaporated in vacuo to provide the title compound (310 g, 71%) as a pale yellow oil.

Provenance & Evidence