Acetyl chloride → HCID 70293601, compound

HRID 1003958Notes

Reaction equation

HRID 1003958 reaction equation
[C:1]([Cl:4])(=O)C.[F:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][CH2:13][C:14]([OH:16])=[O:15]>CO>[ClH:4].[CH3:1][O:15][C:14](=[O:16])[CH2:13][NH:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[F:5]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 5171030N-o-Fluorophenylglycine

Product 1

HCID 70293601HCID 70293601, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Acetyl chloride (4 ml) was added cautiously and dropwise to methanol (20 ml) at 0° C. over 2 minutes. When the addition was completed, the 2-fluorophenylglycine (1 g, 5.9 mmol, Aldrich) was introduced in a single portion. The mixture was stirred until dissolved then allowed to stand at RT for 24 hours. The solvent was evaporated then coevaporated twice from toluene to afford the title compound as a white crystalline solid in quantitative yield.

Workup

  1. additionWhen the addition
  2. dissolutionuntil dissolved
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-b05767b5047b479e9cf1f40904d4802b
Source dataset
uspto-grants-2000_04
Patent number
US06048852

Reaction notes

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