Hydrochloric Acid → HCID 18793923, compound

Participants

Reaction Steps

A solution of the N-(S-acetyl-2'-benzyl-3'-mercaptopropionyl)-2-fluorophenylglycine methyl ester of Example 19b (0.2 mmol) in methanol (2 ml) was degassed with argon for 20 minutes then treated with a solution of sodium sulphide (1 mmol) in degassed water (2 ml). After 30-90 minutes, 0.25M aq. HCl (20 ml) was introduced and the mixture extracted with ethyl acetate (3×20 ml). The dried (MgSO4) organic phases were evaporated to give the title compound as a clear oil, an approximately equimolar mixture of diastereoisomers.

Provenance & Evidence