HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-Methyl-phenylglycine methyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | N-Methyl-N-phenyl-glycine | HCID 420843 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-Methyl-phenylglycine methyl ester hydrochloride | HCID 70291077 | 94% |
Reaction Steps
Prepared by Method A of Example 19 but using N-methyl-phenylglycine (prepared in turn from 2-chlorophenylacetic acid and methylamine) (3.5 g) methanol (20 ml) and acetyl chloride (40 ml) over 48 hours. The title compound was obtained in 94% yield, after trituration with methanol, as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06048852 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-3f0ae84401de4753b2d31985f3ef5bd9 |
| Source note | uspto-grants-2000_04 |