Hydroxyamine hydrochloride → HCID 57123040, compound

Participants

Reaction Steps

Hydroxylamine hydrochloride (1.37 g) was added to a stirred solution of ethyl 2-oxo-2-(4-thiazolyl)acetate (2.54 g) in ethanol (50 ml). The mixture was stirred for 3 h, the solvent was evaporated and the residue partitioned between ethyl acetate and sodium bicarbonate solution. The organic phase was washed with brine, dried over magnesium sulphate and evaporated. The residue was recrystallised from ethyl acetate to give the title oxime as a single isomer (1.315 g), m.p. 171-175° C.

Provenance & Evidence