Hydroxyamine hydrochloride → HCID 88259102, compound

Participants

Reaction Steps

Hydroxylarnine hydrochloride (503 mg) was added to a stirred solution of methyl 2-oxo-2-(3-benzothienyl)acetate (790 mg) in methanol (30 ml). When all the solid had dissolved the mixture was allowed to stand overnight. The solvent was evaporated and the residue partitioned between ethyl acetace and water. The organic phase was washed with water and brine, dried over magnesium sulphate and evaporated. The title oxime (622 mg) was isolated as a mixture of isomers by column chromatography of the residue (Kieselgel: 3:1 going to 1:1 hexane:ethyl acetate. νmax (CHCl3)/cm-1 3568, 3296, 1737. δH (250 MHz, CDCl3), 3.90 and 4.00 (3H, two s's), 7.37-7.59 (2H, m), 7.61 and 7.77 (1H, two s's), 8.30 and 9.15 (1H, two broad s's), 8.43-8.47 (1H, m); m/z (EI) 235 (M+).

Provenance & Evidence