1-Acetyl-4-(4-morpholinecarbonyl)-1,4-diazepane → 3,4-Dimethoxy-6-{1-[4-(morpholinecarbonyl)-1,4-diazepan-1-yl]ethylideneamino}-2-(2,2,2-trifluoroethoxy)benzonitrile

HRID 1004036Notes

Reaction equation

HRID 1004036 reaction equation
[C:1]([C:3]1[C:9]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])=[C:8]([O:16][CH3:17])[C:7]([O:18][CH3:19])=[CH:6][C:4]=1[NH2:5])#[N:2].[C:20]([N:23]1[CH2:29][CH2:28][CH2:27][N:26]([C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)=[O:31])[CH2:25][CH2:24]1)(=O)[CH3:21]>ClCCl.CO>[CH3:17][O:16][C:8]1[C:9]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[C:3]([C:4]([N:5]=[C:20]([N:23]2[CH2:29][CH2:28][CH2:27][N:26]([C:30]([N:32]3[CH2:33][CH2:34][O:35][CH2:36][CH2:37]3)=[O:31])[CH2:25][CH2:24]2)[CH3:21])=[CH:6][C:7]=1[O:18][CH3:19])[C:1]#[N:2]

Participants

4

Reactant 2

HCID 155382861-Acetyl-4-(4-morpholinecarbonyl)-1,4-diazepaneHCID 184706522-Cyano-4,5-dimethoxy-3-(2,2,2-trifluoroethoxy)aniline

Product 1

HCID 177736293,4-Dimethoxy-6-{1-[4-(morpholinecarbonyl)-1,4-diazepan-1-yl]ethylideneamino}-2-(2,2,2-trifluoroethoxy)benzonitrile

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The subtitle compound was prepared from 2-cyano-4,5-dimethoxy-3-(2,2,2-trifluoroethoxy)aniline and 1-acetyl-4-(4-morpholinecarbonyl)-1,4-diazepane following the procedure described in Example 10(g) (73%). Rf 0.16 (dichloromethane:methanol 95:5, v/v). MS m/z 514 (MH)+

Sources & evidence

ORD record
ord-760b21b8e3d64a22b477bd76f929f24d
Source dataset
uspto-grants-2000_04
Patent number
US06048864

Reaction notes

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